MSG and Diabetes

Diabetes is a disease of metabolism, where blood sugar is not automatically controlled by the body. This is due either to the pancreas' inability to make enough insulin, which clears excess blood sugar (glucose) from the blood stream, or by the body's resistance to insulin. The result is a blood sugar reading that is too high.

The latest drug to treat both Diabetes AND Obesity is Liraglutide, a GLP-1 drug that also decreases the neurotoxicity of glutamate. It not only reduced blood glucose, but also reduced weight in "MSG-treated" obese rats.  

Type 1 Diabetes

In the search to understand the mechanisms of diabetes because of its unprecedented rise in children, it was learned that roughly 85% of those studied with Type 1 diabetes had antibodies against glutamic acid debarboxylase (GAD) .  GAD is an enzyme the body uses to turn glutamic acid, (glutamate) into gamma amino butyric acid (GABA). 

http://content.nejm.org/cgi/content/short/322/22/1555

http://www.ohiohealth.com/healthreference/reference/B444170C-26F6-49DF-92AC12B7A858173C.htm?category=questions

http://www.diabetes123.com/dictionary/g.htm

Ingesting MSG may present the patient with an excess of glutamate, which the body has trouble converting because the immune system is attacking the very mechanism the body uses to metabolize excess glutamate.   These people already have an excess of an amino acid the body can make - they do not need additional free glutamate in their diet.

Why should MSG matter to a diabetic?

MSG causes a very large insulin response after it is ingested since there are glutamate receptors in the pancreas.  MSG manufacturers state that ingested MSG does not result in a corresponding increase in blood levels of free glutamic acid, but according to the following research done in Canada, ingested MSG DOES result in higher plasma concentrations of free glutamic acid AND higher insulin levels as well:

http://ajpendo.physiology.org/cgi/content/full/278/1/E83 

This study alone makes free glutamic acid's role in diseases like Diabetes extremely relevant to the overuse of MSG and free glutamic acid in our food.

Type 2 Diabetes

It was also learned that 85% of children with Type 2 diabetes also suffer from obesity:

See our page on MSG and Obesity

Taurine

Taurine is now being investigated as a treatment for diabetes per this link:

http://neuro-www.mgh.harvard.edu/neurowebforum/GeneralFeedbackArticles/12.16.9612.19PM.html

We will have soon give taurine its own special page on this site.  Taurine keeps appearing in the research regarding diseases affected by MSG such as epilepsy, vision, atrial fibrillation, and blood pressure, etc, etc...)   Glutamate uses the same transport system as cysteine, taurine's metabolic precursor, hence glutamate competes for uptake with the amino acid the body uses to make taurine.  This could result in MSG overload causing taurine deficiency.  It is interesting to note that MSG Symptom complex shares many of the symptoms of taurine deficiency.

Blood Pressure MSG opens calcium channels, thus constricting blood vessels – this may put diabetics with high blood pressure at risk by negating calcium channel blocker medication.

Since cardiovascular disease is a problem for those with diabetes, it would be wise to avoid any blood vessel constricting foods containing the free amino acids -Tyrosine, Tyramine and Glutamate. This means most fermented foods, as well as MSG, and hydrolyzed protein.

 

In 2008, a drug trial for a Type 2 diabetes drug was stopped because of risk of stroke.

 http://www.sciencedaily.com/releases/2008/02/080206105440.htm

Perhaps here we can shed some light on why:  one popular drug - Metformin - for Type 2 diabetes actually works by stressing the body and ACTIVATING AMPK.  The researchers ASSUMED by using up the available glucose lying around it would cure both obesity AND insulin resistance.  Here at MSGTruth, we believe that the Type 2 diabetes drugs that act this way actually CAUSE insulin resistance and stroke risk:

The following is a study of what happens when AMPK is INHIBITED, nerve cells are PROTECTED during stroke.  http://www.jbc.org/cgi/content/abstract/280/21/20493

Activated AMPK puts the body on high alert and glucose is used.  Unfortunately the body has feedback mechanisms.  The long term effect of this is that the body tries to CONSERVE resources: leptin resistance INCREASES - resulting in a slower metabolic resting rate and a DECREASE in activity - both of which lead to OBESITY.  In addition AMPK actually STOPS the formation of muscle because the body is in a state of fight or flight stress.  Immediate survival takes over for growth of muscle.  And so the body does not increase its amount fat burning muscle.  Low calorie diets at the same time add MORE stress to the situation and increase activation of AMPK further.    The body goes into starvation emergency mode: the hypothalamus ignores leptin, hunger INCREASES, activity DECREASES and the body regains whatever weight was lost by being under stress - and then some.  This is the perfect recipe for insulin resistance and obesity in the end, throw in stroke risk too, and these AMPK activators look like a very BAD idea for weight loss and insulin control.  Especially when you consider that MSG and free glutamic acid found in weight loss diet powders given by DOCTORS to obese Type 2 diabetes patients, raise insulin by directly stimulating the pancreas even if there is NO GLUCOSE EVEN PRESENT. 

CoQ10 is being given to heart patients right now.  CoQ10 deficiency actually INHIBITS AMPK.  Why are we giving ANYONE drugs that ACTIVATE AMPK and stress the body on purpose?  So we can give them expensive glutamate blockers and CoQ10 later?

Artificial Sweeteners

Another unfortunate problem right now is that many diabetics are using artificial sweeteners like  Aspartame (Nutrasweet).  Unfortunately, it contains phenylalinine - the metabolic precursor to tyrosine. Tyrosine is well known to be a blood pressure raiser. This is probably why many people complain of headaches after eating Nutrasweet. Blood vessel constriction can cause headaches. Nutrasweet may actually be dangerous for diabetics, because of its effects on the cardiovascular system.

Fruits and fruit juices already sweeten things well.  Stevia, an herb is also used as a sweetener. Currently agave is a natural sweetener of choice touted by many doctors because it does not cause a spike in insulin levels.  Xylitol is also used lately but with a caveat because it must be metabolized in the liver.

 

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MSG and A.L.S.
MSG and Alzheimer's
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MSG and Atrial Fibrillation
MSG and Autism
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MSG and Cancer
MSG and Celiac Sprue
MSG and Depression
MSG and Diabetes
MSG and Dizziness
MSG and Epilepsy
MSG and Fibromyalgia
MSG and Heat Stroke
MSG and High Blood Pressure
MSG and Hypoglycemia
MSG and Hypothyroidism
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MSG and Inflammation
MSG and Migraine
MSG and MS
MSG and Myopia
MSG and Obesity
MSG and Pituitary Tumors
MSG and Rage/Panic Disorder
MSG and Rosacea
MSG and Sulfite Sensitivity
MSG and Tinnitus
MSG and Sleeplessness

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